AstraZeneca says vaccine 76% effective in updated US trial data
British-Swedish drugmaker AstraZeneca on Wednesday revised down by 3 percentage points the effectiveness of its COVID-19 vaccine after American authorities raised concerns that results reported from its US trial were outdated.
The company now says its vaccine is 76 rather than 79 percent effective at preventing any kind of symptomatic COVID-19.
It remains 100 percent effective against severe COVID-19, it added.
The move came after an independent panel of experts appointed to supervise the trial expressed concern that AstraZeneca had failed to include updated data in its initially released figure.
The US National Institutes of Health then issued a highly unusual statement asking AstraZeneca to work with the panel and issue a new press release.
"We look forward to filing our regulatory submission for Emergency Use Authorization in the US and preparing for the rollout of millions of doses across America," said Mene Pangalos, executive vice president of biopharmaceuticals research and development.
The new figure is based on 190 people who fell sick among 32,449 trial participants across the United States, Peru and Chile, two-thirds of whom received the vaccine while the rest received a placebo.
The previous figure was based on 141 cases, with a cut-off in mid-February.
The company added there are 14 additional or probable COVID-19 cases left to be adjudicated.
Depending on whether these occurred in the vaccine or placebo group, the final efficacy figure could go up or down a few percentage points.
The company added the vaccine efficacy in people 65-years-old and over was 85 percent, but the statistical range for this figure — anywhere between 58 and 95 percent — make it less meaningful and the sample size was not mentioned.
Eight cases of severe COVID-19 occurred — all in the placebo group.
AstraZeneca was an early frontrunner in the global race to develop a COVID vaccine, and was heavily favored by the United States, which ordered 300 million doses — more than its first orders for Moderna's and Pfizer's shots.
But a series of communications blunders eroded US agencies' confidence.
The US now has three authorized vaccines — Moderna, Pfizer and Johnson & Johnson — and should have enough supply to more than cover the adult population by the end of May.